• Accomplishments
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• Research
• Spinal Cord Injury Projects
• Traumatic Brain Injury Projects
  • Assessment & Intervention for Mild TBI
  • Can Eye Movements Predict Persistent Problems in Paediatric Mild TBI?
  • Cognitive and Neural Substrates of Socially Maladaptive Behaviours in Adolescents with Traumatic Brain Injury
  • DECRA Trial (DECompressive CRAniectomy Trial)
  • Enhancing Neurogenesis Post -TBI
  • Fluid Resuscitation in TBI
  • Headstart: Multi-family Groups for Traumatic Brain Injury
  • Hypothermia in Childhood TBI (HiTBIC)
  • Improving the functional communication ability of adults with TBI
  • Long term consequences of childhood head injury - 15 year follow-up
  • Longitudinal Hippocampal Study
  • Measuring the Impact of TBI on People's Lives
  • Mobility Following Childhood TBI
  • New Treatments for Brain and Spinal Cord Injuries
  • Neural Basis of Communication Disorder in Children
  • Neurotrauma Tissue/Fluid Bank
  • Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)
  • Preventing Neuronal Cell Death Following Brain Trauma
  • Prevention and Treatment of Social Problems Following TBI
  • Rehabilitation of Attention Following TBI
  • Role of Tissue Type Plasminogen Activator
  • TBI in Older Adults
  • Transcranial Magnetic Stimulation (TMS) Treatment in Depression After Traumatic Brain Injury
  • Traumatic Hypoxia and Cerebral Inflammation
  • Virtual Reality and Upper Limb Function Following TBI in Children
• Targeted Initiatives
• Completed TBI and SCI Projects
• Program Grants

Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)

The Impact of Glycaemic Control on Mortality and Neurological Function in Traumatic Brain Injury Patients: A Sub-study of a Large Randomised Trial

Chief Investigator: A/ Professor Simon Finfer, Professor John Myburgh
Lead Organisation: Monash University Department of Epidemiology & Preventive Medicine
VNI Funding: $98,797
Project Start Date: 01-Nov-07

Project Summary:
High blood glucose is a common finding in patients who are acutely ill, and is associated with increased risk of adverse outcomes. A recent single-centre randomised controlled trial (RCT) found that intensive insulin therapy reduced hospital deaths by 34% (Van Den Berghe et al. 2001). In analysing the 63 patients in the study with isolated brain injuries, they found a reduction in brain pressures and improved functional outcomes at one year.

In 2005, the Australian and New Zealand Clinical Trials Group commenced a large multicentre RCT (the NICE study), comparing the effects of intensive insulin therapy (blood glucose target 4.5-6.0mmol/L controlled by a proven web-based algorithm) to standard therapy (blood glucose target less than 10mmol/L) on 90 day all-cause mortality in intensive care patients.

The proposed study, "NICE-TBI", will be a sub study of the NICE study. It will focus on the mortality and functional recovery of NICE study patients with traumatic brain injury. It is hypothesised that improved glycaemic control will be protective to the central nervous system. This protection may translate into improved long-term patient outcomes.