Transcranial Magnetic Stimulation (TMS) Treatment in Depression after

The Use of Non-invasive Brain Stimulation in the Treatment of the Sequelae of Closed Brain Injury

Chief Investigator: Professor Paul Fitzgerald
Associate Investigators: Professor Jayashri Kulkarni, Ms Jacqueline Anderson, Dr Yitzchak Hollander
Lead Organisation: Monash University
VNI Funding: $502,950
Project Start Date: 10-Jun-08

Project Summary:
Depression is very common in people who have experienced a traumatic brain injury. Few treatments have been found to be effective in treating depression in this situation. Repetitive transcranial Magnetic Stimulation (rTMS) is a non-invasive technique that uses short bursts of magnetic energy to stimulate nerve cells in the brain that has been found to be an effective treatment for depression in people without a brain injury. We will investigate the effectiveness of TMS for treating depression in people with a brain injury. We will do this by conducting a standard placebo controlled trial. Participants will receive daily treatment over a 4 week period of time. Participants who receive the placebo treatment will be offered active treatment after that time. It is anticipated that 50 patients will be recruited for the study. Participants will be between the ages of 18-70 years and will be at least 6 weeks post brain injury and will have experienced a major depressive episode.