• Accomplishments
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• Research
• Spinal Cord Injury Projects
• Traumatic Brain Injury Projects
  • Assessment & Intervention for Mild TBI
  • Can Eye Movements Predict Persistent Problems in Paediatric Mild TBI?
  • Cognitive and Neural Substrates of Socially Maladaptive Behaviours in Adolescents with Traumatic Brain Injury
  • DECRA Trial (DECompressive CRAniectomy Trial)
  • Enhancing Neurogenesis Post -TBI
  • Fluid Resuscitation in TBI
  • Headstart: Multi-family Groups for Traumatic Brain Injury
  • Hypothermia in Childhood TBI (HiTBIC)
  • Improving the functional communication ability of adults with TBI
  • Long term consequences of childhood head injury - 15 year follow-up
  • Longitudinal Hippocampal Study
  • Measuring the Impact of TBI on People's Lives
  • Mobility Following Childhood TBI
  • New Treatments for Brain and Spinal Cord Injuries
  • Neural Basis of Communication Disorder in Children
  • Neurotrauma Tissue/Fluid Bank
  • Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)
  • Preventing Neuronal Cell Death Following Brain Trauma
  • Prevention and Treatment of Social Problems Following TBI
  • Rehabilitation of Attention Following TBI
  • Role of Tissue Type Plasminogen Activator
  • TBI in Older Adults
  • Transcranial Magnetic Stimulation (TMS) Treatment in Depression After Traumatic Brain Injury
  • Traumatic Hypoxia and Cerebral Inflammation
  • Virtual Reality and Upper Limb Function Following TBI in Children
• Targeted Initiatives
• Completed TBI and SCI Projects
• Program Grants

Enhancing Neurogenesis Post - TBI

Enhancing Endogenous Neurogenesis as a Potential Therapy Following Traumatic Brain Injury (Pilot Study)

Chief Investigator: Associate Professor Cristina Morganti-Kossmann
Lead Organisation: Bayside Health
VNI Funding: $164,899
Project Start Date: 01-Jul-07

Project Summary:
Traumatic brain injury is the major cause of death in the population below the age of 40 years. Approximately 25% of individuals that survive head injury remain with permanent neurological disabilities. At the basis of this disability is the massive loss of brain cells (neurons) that occurs after trauma. The brain tissue presents a limited capacity to regenerate and replenish the cells that have been lost after injury. Although the brain has historically been considered a non-regenerating tissue, in recent years, neuroscientists identified immature cells in normal brain that have the potential to grow and differentiate into functional neurons. This process is defined as neurogenesis. This pilot project will investigate the neurogenesis that occurs following focal traumatic brain injury in mice. We will study the time course of neurogenesis induced by traumatic brain injury, and will determine how this relates to the proliferation and activation of glial cells. The results of may potentially lead to improved tissue repair and neurological function and may assist in the development of new therapies for head injured patients.

This project has been completed. Read the final summary.