• Accomplishments
• Contact

• Research
• Spinal Cord Injury Projects
• Traumatic Brain Injury Projects
  • Assessment & Intervention for Mild TBI
  • Can Eye Movements Predict Persistent Problems in Paediatric Mild TBI?
  • Cognitive and Neural Substrates of Socially Maladaptive Behaviours in Adolescents with Traumatic Brain Injury
  • DECRA Trial (DECompressive CRAniectomy Trial)
  • Enhancing Neurogenesis Post -TBI
  • Fluid Resuscitation in TBI
  • Headstart: Multi-family Groups for Traumatic Brain Injury
  • Hypothermia in Childhood TBI (HiTBIC)
  • Improving the functional communication ability of adults with TBI
  • Long term consequences of childhood head injury - 15 year follow-up
  • Longitudinal Hippocampal Study
  • Measuring the Impact of TBI on People's Lives
  • Mobility Following Childhood TBI
  • New Treatments for Brain and Spinal Cord Injuries
  • Neural Basis of Communication Disorder in Children
  • Neurotrauma Tissue/Fluid Bank
  • Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)
  • Preventing Neuronal Cell Death Following Brain Trauma
  • Prevention and Treatment of Social Problems Following TBI
  • Rehabilitation of Attention Following TBI
  • Role of Tissue Type Plasminogen Activator
  • TBI in Older Adults
  • Transcranial Magnetic Stimulation (TMS) Treatment in Depression After Traumatic Brain Injury
  • Traumatic Hypoxia and Cerebral Inflammation
  • Virtual Reality and Upper Limb Function Following TBI in Children
• Targeted Initiatives
• Completed TBI and SCI Projects
• Program Grants

Preventing Neuronal Cell Death Following Brain Trauma

Preventing Neuronal Cell Death Following Brain Trauma

Chief Investigator: Professor Seong-Sen Tan
Associate Investigators: Associate Professor Cristina Morganti-Kossmann, Professor Thomas Kossmann, Professor Sharad Kumar, Professor David Vaux, Dr John Silke
Lead Organisation: Howard Florey Institute
VNI Funding: $1,662,375
Project Start Date: 01-Nov-06

Project Summary:
This project aims to develop a strategy to limit neuronal death following traumatic brain injury. This strategy focuses on saving `what’s left behind’ in order to limit the effects of secondary brain injury. This project will focus on a new protein (Nedd4 WW-domain binding protein, N4WBP5), that was initially discovered and cloned in Australia, and through preliminary experiments has been shown to be capable of saving stressed neurons from dying. The short-term aims of this project are to improve our understanding of the function of N4WBP5 in neuroprotection using cultured neurons and animal models. The long-term aims are to extend studies into human cells and tissue, ultimately conducting therapeutic trials of N4WBP5 in traumatically brain injured patients.