• Accomplishments
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• Research
• Spinal Cord Injury Projects
• Traumatic Brain Injury Projects
  • Assessment & Intervention for Mild TBI
  • Can Eye Movements Predict Persistent Problems in Paediatric Mild TBI?
  • Cognitive Neuroscience of Maladaptive Behaviours in Adolescents with Traumatic Brain Injury
  • DECRA Trial (DECompressive CRAniectomy Trial)
  • Enhancing Neurogenesis Post -TBI
  • Fluid Resuscitation in TBI
  • Headstart: Multi-family Groups for Traumatic Brain Injury
  • Hypothermia in Childhood TBI (HiTBIC)
  • Improving the functional communication ability of adults with TBI
  • In Vivo Hippocampal Studies in Rats
  • Long term consequences of childhood head injury - 15 year follow-up
  • Measuring the Impact of TBI on People's Lives
  • Mobility Following Childhood TBI
  • New Treatments for Brain and Spinal Cord Injuries
  • Neural Basis of Communication Disorder in Children
  • Neurotrauma Tissue/Fluid Bank
  • Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)
  • Preventing Neuronal Cell Death Following Brain Trauma
  • Prevention and Treatment of Social Problems Following TBI
  • Rehabilitation of Attention Following TBI
  • Role of Tissue Type Plasminogen Activator
  • TBI in Older Adults
  • Transcranial Magnetic Stimulation (TMS) Treatment in Depression After Traumatic Brain Injury
  • Traumatic Hypoxia and Cerebral Inflammation
  • Virtual Reality and Upper Limb Function Following TBI in Children
• Targeted Initiatives
• Completed TBI and SCI Projects
• Program Grants

Neuronal Cell Death Post Trauma

Preventing Neuronal Cell Death Following Brain Trauma

Chief Investigator: Professor Seong-Sen Tan
Associate Investigators: Associate Professor Cristina Morganti-Kossmann, Professor Thomas Kossmann, Professor Sharad Kumar, Professor David Vaux, Dr John Silke
Lead Organisation: Howard Florey Institute
VNI Funding: $1,662,375
Project Start Date: 01-Nov-06

Project Summary:
This project aims to develop a strategy to limit neuronal death following traumatic brain injury. This strategy focuses on saving `what’s left behind’ in order to limit the effects of secondary brain injury. This project will focus on a new protein (Nedd4 WW-domain binding protein, N4WBP5), that was initially discovered and cloned in Australia, and through preliminary experiments has been shown to be capable of saving stressed neurons from dying. The short-term aims of this project are to improve our understanding of the function of N4WBP5 in neuroprotection using cultured neurons and animal models. The long-term aims are to extend studies into human cells and tissue, ultimately conducting therapeutic trials of N4WBP5 in traumatically brain injured patients.

This project is complete. Click here to read the full summary.