• Accomplishments
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• Research
• Spinal Cord Injury Projects
• Traumatic Brain Injury Projects
  • Assessment & Intervention for Mild TBI
  • Can Eye Movements Predict Persistent Problems in Paediatric Mild TBI?
  • Cognitive Neuroscience of Maladaptive Behaviours in Adolescents with Traumatic Brain Injury
  • DECRA Trial (DECompressive CRAniectomy Trial)
  • Enhancing Neurogenesis Post -TBI
  • Fluid Resuscitation in TBI
  • Headstart: Multi-family Groups for Traumatic Brain Injury
  • Hypothermia in Childhood TBI (HiTBIC)
  • Improving the functional communication ability of adults with TBI
  • In Vivo Hippocampal Studies in Rats
  • Long term consequences of childhood head injury - 15 year follow-up
  • Measuring the Impact of TBI on People's Lives
  • Mobility Following Childhood TBI
  • New Treatments for Brain and Spinal Cord Injuries
  • Neural Basis of Communication Disorder in Children
  • Neurotrauma Tissue/Fluid Bank
  • Normoglycaemia in Intensive Care Traumatic Brain Injury Study (NICE-TBI)
  • Preventing Neuronal Cell Death Following Brain Trauma
  • Prevention and Treatment of Social Problems Following TBI
  • Rehabilitation of Attention Following TBI
  • Role of Tissue Type Plasminogen Activator
  • TBI in Older Adults
  • Transcranial Magnetic Stimulation (TMS) Treatment in Depression After Traumatic Brain Injury
  • Traumatic Hypoxia and Cerebral Inflammation
  • Virtual Reality and Upper Limb Function Following TBI in Children
• Targeted Initiatives
• Completed TBI and SCI Projects
• Program Grants

In Vivo Hippocampal Studies in Rats

Longitudinal In Vivo Study of Hippocampal Structure and Function, and Relationship to Neurocognitive, Neurobehavioral and Epileptic Outcomes, in a Model of Human Traumatic Brain Injury

Chief Investigators: Associate Professor Terence O’Brien, Dr Damien Myers, Professor Rod Hicks
Associate Investigators: Associate Professor David Howells, Mr John Williams, Dr Dennis Velakoulis, Professor Chris Pantelis, Associate Professor Gary Egan, Dr Stefanie Dedeurwaerdere, Dr Nigel Jones, Associate Professor Edward Hogan, Dr Peter Batchelor, Dr Bianca Jupp, Dr Ke Fang
Lead Organisation: University of Melbourne
VNI Funding: $973,324
Project Start Date: 09-Oct-06

Project Summary:
Deficits in cognition, changes in behaviour and epileptic seizures are common and disabling long-term consequences of traumatic brain injury. Brain scans, such as CT or MRI, will often identify sites of damage, however, no systematic study has been performed to identify how changes to the injured brain are associated with behavioural changes after traumatic brain injury. The purpose of this study is to investigate the nature of progressive damage in the brain that continues long after the acute effects have resolved and identify targets for future interventions. This study will be performed using an animal model of closed head injury with advanced imaging techniques applied before and after the injury.

This project is completed. Click here to read the full summary.