EphA4 Peptide Inhibitors for Neurotrauma Treatment
Development of EphA4 Peptide Inhibitors for the Treatment of Neurotrauma
Chief Investigator: Associate Professor Ann Turnley
Associate Investigators: Dr Tony Hughes, Dr Yona Goldschmidt
Lead Organisation: University of Melbourne
VNI Funding: $573,647
Project Start Date: 07-May-07
Project Summary:
Ephs and ephrins are molecules found on the surface of cells. They recognise and bind to one another, thus providing a means for cells to communicate. Several of these molecules are found in the spinal cord and their expression is increased when the spinal cord is damaged. In this project, computer-aided molecular modelling approaches will be used to design small peptide molecules that block the interaction of one particular Eph molecule, called EphA4 and ephrins. The molecules will be synthesised and purified, then examined for their effects on nerve cell growth and spinal cord regrowth. By the end of the two year project period, a panel of novel molecules will have been tested for their ability to block EphA4 actions in cell culture and in animal models. In the longer term, these compounds may act as lead compounds for further development as regenerative therapy for spinal cord damage following traumatic injury.
